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I even tried to help him with sulbutiamine as my dads symptoms were very similar to Beriberi disease, which sulbutiamine was made to treat

We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)